2025 PSI Graham Farquharson KT Fellow at the Starting Line: Passing the Baton to Dr. Lucy Barker

Upon receiving their approval letters and sharing the exciting news of the award with their community, the PSI Knowledge Translation (KT) Fellows begin preparing to get settled in their place at the starting line. As they embark on their KT Fellowship journey, we asked them few questions to know them beyond their recipient biographies, as well as some notes they could pass on to future applicants. 

Please use 3 words to describe how you feel as you begin your KT Fellowship.

Excited, honoured, motivated

Why did you apply for the PSI KT Fellowship? How does this award align with your current research and career goals?

I applied for the PSI KT Fellowship to facilitate having more dedicated time for knowledge translation related to my research on youth reproductive mental health. My goal is to do research and implementation work that has a substantive positive impact on reproductive and mental health outcomes. The Fellowship affords me time to engage knowledge users including clinicians, community organizations, and youth with lived experience, and translate research findings into clinical care and services.

What are 3 to 5 general tips and notes you would pass on to those preparing their KT Fellowship application?

  • This is a great opportunity for early career physicians to develop their knowledge translation programs including building relationships with community organizations and people with lived experience.
  • When preparing your application, consider how knowledge can be translated not only into new projects, but also into existing clinical services to improve care.
  • Keep trying! This was not my first time applying for a PSI KT Fellowship.

New PSI Funding Opportunity: 2026 PSI Graham Farquharson Knowledge Translation (KT) Fellowship

PSI Launches the 2026 Competition for the PSI Graham Farquharson Knowledge Translation Fellowship

PSI Foundation is very pleased to announce the 2026 competition for the PSI Graham Farquharson Knowledge Translation Fellowship. This Fellowship is intended to provide salary support for a new investigator who has demonstrated the ability to successfully complete high impact knowledge translation research. The Fellowship funds, dedicated to salary support, must protect at least 50% of the Fellow’s time to conduct such research.

Please note: This funding opportunity is not an additional PSI operating grant. Knowledge translation must be the fundamental purpose of this Fellowship and must be demonstrated in the application.

Amount and Duration of Funding

This program offers two options for a funding timeline for salary support: A maximum of $150,000 per year for two years; OR a maximum of $100,000 per year for three years.

Please note: the award is intended to protect at least 50% of the fellow’s time to undertake research, regardless of whether the award is taken over two or three years.

Eligibility of Candidate

For this competition, PSI has set the eligibility criteria for candidates as follows:

The candidate for the Fellowship must be either:

  • Within six (6) years of their first academic appointment and have demonstrated potential for high impact research work
    • Please note: PSI has adjusted this eligibility requirement in recognition of the impact of the COVID-19 pandemic
  • Dedicating at least 50% of a full-time schedule to the Fellowship
  • A practising physician with a College of Physicians and Surgeons of Ontario (CPSO) licensed M.D. having direct patient care responsibilities and an academic appointment, thus eligible to apply for their own research grants as an independent investigator.

OR

  • A clinical fellow in Ontario who is a practising physician having direct patient care responsibilities, with a supervisor who has an academic appointment and that can provide the necessary research supervision and infrastructure (including administering the grant at the sponsoring institution). A letter of support from this supervisor must be included in the application.

The PSI Graham Farquharson Knowledge Translation Fellow is able to apply to PSI for an operating grant (e.g. New Investigator grant).

Important Information in Funding Guidelines

The Funding Guidelines contain important information regarding the award, including PSI’s definition of knowledge translation, sponsoring institution requirements, and funding criteria.

Please review this document before applying.

How to Apply

Similar to the previous years, PSI is launching this competition through a Letter of Intent (LOI) process. Please note that for this competition, applicants are required to submit their applications directly to PSI, not through the institution.

We require all applicants to submit the completed LOI directly to PSI via the PSI Online Grants Management System (https://psifoundation.smartsimple.ca/) by June 9th, 2025 at 5pm EST. LOIs will be reviewed by the PSI Grants Committee in July 2025.

PSI will invite successful applicants to submit full applications by October 20th, 2025 at 5pm EST, which will undergo peer review and committee review for a final funding decision in December 2025.

Questions?

Please contact the PSI Office to discuss any questions you may have about submitting an application for funding.

New PSI Funding Opportunity: 2026 PSI Mid-Career Knowledge Translation (KT) Fellowship

PSI acknowledges that mid-career can be a challenging time for physician researchers. During this phase, there are often additional academic roles and responsibilities including committee work, leadership positions, and mentoring of junior investigators, while clinical work continues. PSI recognizes the importance in supporting this phase of an investigator’s trajectory.

PSI Launches the 2026 Competition for the PSI Graham Farquharson Knowledge Translation Fellowship

PSI Foundation is very pleased to announce the 2026 competition for the PSI Mid-Career Knowledge Translation Fellowship. This Fellowship is intended to provide salary support for a mid-career physician researcher in Ontario who has demonstrated the ability to successfully complete high-impact knowledge translation research. The Fellowship funds, dedicated to salary support, must protect at least 50% of the Fellow’s time to conduct such research.

Please note: Knowledge translation must be the fundamental purpose of this Fellowship and must be demonstrated in the application.

Amount and Duration of Funding

Total Support

This program offers two options for a funding timeline for salary support:

A maximum of $400,000 over two years;

OR

A maximum of $400,000 over three years.

The award is intended to protect at least 50% of the fellow’s time to undertake research, regardless of whether the award is taken over two or three years.

Matching Funding Requirements

The sponsoring institution is required to fund 50% of the total award.

For example, if the fellow requests a total support of $400,000 over two years, then PSI will fund $200,000 over two years ($100,000 per year) and the institution is required to co-fund $200,000 over two years ($100,000 per year).

Eligibility

For this competition, the candidate for the Fellowship must be:

  • A practicing physician in Ontario with a College of Physicians and Surgeons of Ontario licensed M.D. having direct patient care responsibilities and an academic appointment, thus eligible to apply for their own research grants as an independent investigator
  • Within six (6) to fifteen (15) years of their first academic appointment and have demonstrated potential for high impact research work
  • Dedicating at least 50% of a full-time schedule to the Fellowship

The PSI Mid-Career Knowledge Translation Fellow is able to apply to PSI for an operating grant (e.g. Clinical Research grant).

Important Information in Funding Guidelines

The Funding Guidelines contain important information regarding the award, including PSI’s definition of knowledge translation, matching funding requirements, and funding criteria.

Please review this document before applying.

How to Apply

PSI is launching this competition through a Letter of Intent (LOI) process. Please note that for this competition, applicants are required to submit their applications directly to PSI, not through their institution.

We require all applicants to submit the completed LOI directly to PSI via the PSI Online Grants Management System (https://psifoundation.smartsimple.ca/) by June 9th, 2025 at 5pm EST. LOIs will be reviewed by the PSI Grants Committee in July 2025.

PSI will invite successful applicants to submit full applications by October 20th, 2025 at 5pm EST, which will undergo peer review and committee review for a final funding decision in December 2025.

Questions?

Please contact the PSI Office to discuss any questions you may have about submitting an application for funding.

Meet the PSI Chair: Q&A with Dr. Naana Jumah

About Dr. Naana Jumah

Dr. Naana Jumah is an Obstetrician Gynaecologist at the Thunder Bay Regional Health Sciences Centre and Assistant Professor at the Northern Ontario School of Medicine (NOSM). She holds an undergraduate degree in Chemical Engineering from the University of Toronto and a DPhil in Medical Engineering from the University of Oxford, which she completed as a Rhodes Scholar.

She graduated from Harvard Medical School and completed her residency in Obstetrics and Gynaecology with a specialization in Addiction Medicine at the University of Toronto. Dr. Jumah’s clinical practice and research focuses on Indigenous women’s health and addiction in pregnancy in Northwestern Ontario. She has won numerous awards for her work and advocacy in Indigenous maternal health, including the Carl Nimrod Educator Award from the Society of Obstetricians and Gynecologists of Canada.

Questions & Answers:

1. Could you use three words to describe how you feel about your new role as the PSI Chair?
“Determined, inspired and progressive.”

2. What inspired you to pursue medicine—specifically in obstetrics and gynaecology?
“I started off as an engineer and really loved the problem-solving aspect of the job, but I found it wasn’t as fulfilling for me because I missed the experience I had through volunteer work in Northwestern Ontario in advocacy and social justice where you really get involved in people’s lives.”

“Through my engineering doctoral research, I had the opportunity to collaborate with a physician and saw how, through medicine, I could combine research, problem-solving on a human scale, and social justice in one. Once I got into medicine, obstetrics and gynaecology chose me – I love the patient population; I love the variety of clinic, procedures and surgery; I love that you can have a meaningful impact in women’s lives through advances in research.”

3. What are the most memorable moments of your career thus far?
“In Obstetrics & Gynaecology, you are part of such pivotal moments in people’s lives in a way that you don’t get to be in other aspects of medicine. Day-to-day, that is incredibly rewarding. The PSI Graham Farquharson KT Fellowship played a pivotal role in establishing my research career. The award also legitimised the type of research I wanted to do at an institution that did not have dedicated clinician scientists. Without that Fellowship and the external validation it provided, I would have never been able to work with women in remote First Nations communities to co-create research priorities that addressed their reproductive health needs or to advocate for the return of Indigenous midwifery to Northwestern Ontario. While the day-to-day interaction with patients is rewarding, the impact that I can achieve through research truly brings me joy.”

4. How do you bring your experience and expertise as an obstetrician gynaecologist and clinician researcher to your role as a member of PSI’s committees, and more recently as the Chair of PSI?
“My background definitely gives me a different perspective on research, clinical practice, and health care philanthropy. Women’s health has always been marginalized from mainstream research and so has research including people living in northern, rural and remote communities. Those populations are the focus of my clinical practice and my research. They are also representative of me personally as an immigrant woman who has lived in Northwestern Ontario for over 40 years. But I also have experience working in large urban academic centres and maintain an appointment at the University of Toronto. Because of this, in Board and Committee meetings, I am able to bridge understanding from multiple research spaces: urban vs rural; resourced vs under-resourced; academic vs community-based; mainstream vs marginalized.”

5. You are one of the first PSI Graham Farquharson Knowledge Translation (KT) Fellows to become involved with PSI Foundation; you first became a committee member and now you are the PSI Chair. Can you tell us what motivated you to become involved with PSI Foundation?
“The PSI Foundation provided me with a tremendous opportunity to kick-start my career as a clinician scientist. For that, I will be forever grateful. The best way I could think of to show my gratitude for that opportunity was to become involved with PSI and hopefully pay it forward to another researcher whose life may also be transformed by a fellowship. Initially, I was invited to sit in on the PSI Grants Committee. It took a few meetings to get a sense of the organisation and the expectations but once I did, I was hooked. Almost ten years later, I am now the Chair of the Foundation—something I would’ve never dreamed of at that first Grants Committee meeting.”

6. What are your goals for PSI as the Chair?
“As PSI Chair, I would like to raise the profile of PSI Foundation and make it the recognised home for physician-led research in Ontario. We have been funding physician-led research for over 50 years and we have granted over $155 million in that time. However, if you were to ask the average clinician scientist who we are or what we do, I think there would be little awareness of the organisation and the impact we have had. At 50 plus years, we have the opportunity to build on the legacy we have established and transform into an organization that is responsive to a changing research landscape and the changing health needs of the people of Ontario. We can do more to build community amongst clinician researchers from medical school, through residency, fellowship and into practice.”

7. What do you think the future of PSI will look like?
“I’m not sure. I like surprises.”

Two Physician Researchers Awarded: 2025 PSI Graham Farquharson Knowledge Translation (KT) Fellowship

The PSI Graham Farquharson Knowledge Translation Fellowship – valued at $300,000 for over two or three years – helps protect a promising physician’s research time, allowing the Fellow to undertake high-impact translational research in Ontario.

Two Physician Researchers Awarded with the 2025 PSI Graham Farquharson Knowledge Translation (KT) Fellowship

PSI Foundation is pleased to name two physician researchers as the 2025 PSI Graham Farquharson KT Fellowship recipients:

Dr. Lucy Barker – Women’s College Hospital (Recipient Biography)

Dr. Nicole Kozloff – Centre for Addiction and Mental Health (CAMH) (Recipient Biography)

Please visit their recipient biographies for more information on each of these Fellows and how they will be using PSI funds to conduct high-impact knowledge translation research. We thank all stakeholders for supporting PSI with the 2025 competition.

PSI’s Commitment to Funding KT Research for Early Career Physician Researchers in Ontario

Knowledge translation research is aimed at taking research discoveries and moving them into the real world to improve health outcomes. PSI’s KT Fellowship program focuses on translational research that is multi-disciplinary and multi-method, focused on improving the processes of care and/or outcomes of medical care for Ontarians.

Since the launch of this award in 2012, PSI has invested over $7.4 million in funding 25 physician researchers in Ontario with the PSI Graham Farquharson Knowledge Translation Fellowship.

2026 Competition to Open in Spring 2025

PSI plans to launch the competition for the 2026 PSI Graham Farquharson KT Fellowship in Spring 2025. Please follow us on X (Twitter) @PSIFoundation and subscribe to our mailing list to stay updated and connected with our latest news!

Dr. Nicole Kozloff: 2025 PSI Graham Farquharson Knowledge Translation (KT) Fellowship Recipient

“Despite the significant burden of mental health challenges among youth in Canada, only a minority access appropriate services. This is true even for the subset of youth who have particularly complex needs, as there are few evidence-based, implementable interventions designed for them. My research engages service users and providers to adapt interventions for youth with complex mental health needs and evaluate them. By considering implementation from the outset, we can connect youth with the treatment that best meets their needs earlier in the course of illness and improve their outcomes.” – Dr. Nicole Kozloff

PSI Foundation is pleased to announce Dr. Nicole Kozloff as the recipient of the 2025 PSI Graham Farquharson Knowledge Translation Fellowship.

About Dr. Nicole Kozloff

Dr. Nicole Kozloff is a scientist, child and adolescent psychiatrist and the co-director of the Slaight Family Centre for Youth in Transition at the Centre for Addiction and Mental Health (CAMH). She is also an associate professor in the Department of Psychiatry and the Institute of Health Policy, Management and Evaluation at the University of Toronto.

Dr. Kozloff’s research aims to improve the accessibility and effectiveness of services for youth with complex mental health needs and their families. To date, she has been awarded over $14,000,000 in research funding as Principal Investigator (PI) or co-PI. Having benefitted from support and guidance from mentors, she has contributed to several mentorship activities for junior psychiatrists and other scientists, and recently received the CIHR – CPA Glenda M. MacQueen Memorial Career Development Award for Women in Psychiatry.

About the PSI Graham Farquharson Knowledge Translation Fellowship

Knowledge translation research aims at transitioning research discoveries to the real world to improve health outcomes. The PSI Graham Farquharson Knowledge Translation Fellowship – valued at $300,000 for over two or three years – helps protect a promising new clinician investigator’s research time, allowing the Fellow to undertake high-impact translational research in Ontario.

Dr. Kozloff highlights the significance of salary support awards for physician researchers at the early career level.

“Thoughtfully designing research and authentically engaging with end users to improve our health system takes time, yet there are so few opportunities for salary support for early-career physician researchers. The PSI Graham Farquharson Knowledge Translation Fellowship is a rare example of an award that protects the time of physician researchers from the other demands of their busy careers. This allows physician researchers to apply their unique combination of clinical and scientific expertise to help bring research innovations to the real work.”

Fellowship Funds to be Used to Improve the Outcomes for Youth with Complex Mental Health Needs

A subset of Canadian youth has “complex” mental illness, with a major impact on functioning, extensive use of services, multiple mental or physical health conditions, or challenges related to the social determinants of health. For youth with psychosis, early psychosis intervention (EPI) programs are effective in research settings, but quality of care in real-world settings is inconsistent, and outcomes vary by the social determinants of health—they need structures and processes to support consistent, high-quality EPI service delivery, explicitly designed to address equity gaps. For youth with complex mental health needs other than psychosis, few well-articulated models of care exist, and promising practices are not always rigorously evaluated or spread beyond single settings—they need evidence-based, youth-friendly models informed by those with lived experience, addressing a broad range of needs, that can be implemented across different settings.

This Fellowship aims to implement the NAVIGATE model of coordinated specialty care, digitizing it to support training and uptake, incorporating processes to address the social determinants of health, and adapting it for youth with other complex mental health needs. These projects bring the evidence-based NAVIGATE model to the real world to improve outcomes for youth with the greatest mental health burden.

 

Dr. Lucy Barker: 2025 PSI Graham Farquharson Knowledge Translation (KT) Fellowship Recipient

“Addressing youth mental health and reproductive health in an integrated way has the potential to reduce barriers to care and improve wellbeing. This work, supported by the PSI Graham Farquharson Knowledge Translation Fellowship, aims to improve sexual and reproductive healthcare for Ontario youth with psychosis, and improve mental healthcare for pregnant and postpartum youth.” – Dr. Lucy Barker

PSI Foundation is pleased to announce Dr. Lucy Barker as the recipient of the 2025 PSI Graham Farquharson Knowledge Translation Fellowship.

About Dr. Lucy Barker

Dr. Lucy Barker is an Assistant Professor in the Department of Psychiatry at the University of Toronto, a Psychiatrist and an Early Career Scientist at Women’s College Hospital, and an Adjunct Scientist at ICES.

Dr. Barker’s research focuses on the intersection of reproductive and mental health, and equitable access to mental health services. Her current work specifically aims to improve reproductive mental health services for adolescents and transition-age youth.

Dr. Barker has demonstrated productivity as an early career Clinician-Scientist (including 43 journal article publications, 19 as a first or senior responsible author). She has received numerous awards for her research, including a Canadian Institutes of Health Research (CIHR) Frederick Banting and Charles Best Canada Graduate Scholarships Doctoral Award, two Pat Martens Memorial Student Prizes in Maternal and Child Health Research (Canadian Association of Health Services and Policy Research), and the Dr. Jack V. Tu Memorial Award for Excellence (IHPME). She has also taken on leadership roles to improve mentorship in the field of reproductive mental health.

About the PSI Graham Farquharson Knowledge Translation Fellowship

Knowledge translation research aims at transitioning research discoveries to the real world to improve health outcomes. The PSI Graham Farquharson Knowledge Translation Fellowship – valued at $300,000 for over two or three years – helps protect a promising new clinician investigator’s research time, allowing the Fellow to undertake high-impact translational research in Ontario.

Dr. Barker highlights the importance of salary support awards for physician researchers at the early career level.

“Salary support to conduct research and knowledge translation work is critical for early career physician researchers. The support provided by the PSI Graham Farquharson Knowledge Translation Fellowship will allow me time to conduct research, implement findings in clinical practice, supervise students, and engage with stakeholders including community partners and youth with lived experience. I am incredibly grateful for this support.”

Fellowship Funds to be Used to Improve Care for Youth in Ontario, Integrating Both Reproductive Health and Mental Health

Mental health problems and reproductive health are highly intertwined for youth. Youth who are pregnant or recently delivered a baby are at high risk of experiencing mental illness, and youth with psychosis have higher rates of abortion compared to their unaffected peers. Yet, services that incorporate both reproductive health and mental health for youth are lacking. This project aims to improve care that integrates both reproductive health and mental health for youth in Ontario.

The project has two overlapping components, both of which fill critical gaps in reproductive and mental health services for youth. In the first, Dr. Barker and her colleagues will use new knowledge from their research about the mental health of pregnant and postpartum Ontario youth to improve current services, and to implement and evaluate a new virtual therapy group for postpartum youth. In the second, Dr. Barker and her colleagues will implement and evaluate a sexual and reproductive health module they recently created for women, transgender, and non-binary youth receiving care within early psychosis intervention programs. Throughout, Dr. Barker and her colleagues will engage with youth with lived experience, community organizations, clinicians, and clinical and health systems leaders to incorporate diverse perspectives and maximize impact.

2023 PSI Mid-Career KT Fellow Update: Dr. Daniel McIsaac Keeps the Race Going

Once our PSI Knowledge Translation (KT) Fellows take off from the starting line, they make strides as they move their knowledge translation activities and research program forward. As the finish line becomes clearer in their sight, we asked our fellows some questions to share their progress thus far, and what they look forward to in the remainder of their KT Fellowship.

What are some of your accomplishments from the KT Fellowship thus far?

The overarching objective of my research program, and my PSI Mid-Career KT Fellowship plan, is to use best practices in knowledge translation to support evidence-based implementation of effective prehabilitation for surgical patients in Ontario. I’m excited to report that, thanks to support from key funders like PSI, our team has made meaningful advancements toward this goal!

First, we have recently enrolled our 850th and final participant into the PREPARE Trial, an 11-center randomized controlled trial that is testing whether a home-based prehabilitation program specifically designed with, and for, older patients with frailty will lead to lower rates of patient reported disability after surgery and prevent post-surgery complications. This is currently the largest prehabilitation trial ever completed, and one of the largest trials ever specific to frailty. By early fall 2024 we will have final results, and our findings should immediately impact how we provide preoperative care for some of our highest-risk and most vulnerable surgical patients.

Next, through completion of this 850-patient trial carried out in hospitals throughout Ontario and across Canada, we’ve learned a lot about the practical aspects of delivering prehabilitation. Lessons learned include: (1) how to identify and enroll patients in prehabilitation programs far enough in advance of surgery that they have time to meaningfully improve their health before they go to the operating room; (2) how to deliver home-based prehabilitation to a diverse patient population spread widely across geographic areas; (3) what barriers patients face in trying to complete prehabilitation at home; and (4) how to support patients who have a variety of barriers to improving their exercise and nutritional behaviors in having high levels of adherence to their prehabilitation programs. Recognizing that an important secondary objective of our PREPARE trial would be not only to estimate whether prehabilitation works, but also to learn how to make it work most effectively, we had built structured assessments into our trial that are helping us to develop an evidence-based ‘prehabiliation playbook’ to support future implementation. As the PREPARE Trial winds down, we are beginning to bring these important process data and lessons learned together into a format that can inform our team’s future work, as well as the field of prehabilitation generally.

As our team’s approach to research is to constantly learn from our own experiences and the work of others in the field, while partnering with the patients, clinicians and health system leaders who will be directly involved in prehabilitation implementation, a big part of our work involves reviewing, analyzing, and synthesizing data from across the field of prehabilitation. This approach lets us identify key areas where new and more research is needed, while also allowing us to identify aspects of prehabiliation that are ready for implementation. Since being funded by PSI, our Canadian Prehabilitation Knowledge Network has completed a systematic review of all prehabilitation randomized trials ever conducted. In fact, we are now beginning to partner with groups that are involved in writing clinical practice guidelines to transform our review into a ‘living’ systematic review. Using this approach, every six months we update our search and identify all of the newly published prehabilitation trials. This allows us to have an up to date database of trials (currently numbering over 250) that our team, our partners and collaborators can use to inform their research, practice and guidelines in a tremendously efficient manner. For our team, we’ve just completed our first analyses of the database. These analyses have let us evaluate what combinations of prehabiliation components (i.e., exercise, nutrition, cognitive or psychosocial interventions), and individual components, are most likely to reduce complication rates and length of stay, and improve quality of life and physical recovery. Our findings show that on their own, exercise- and nutrition-based prehabilitation, along with multicomponent programs that include exercise, may improve outcomes in a clinically meaningful manner. Our review also demonstrates that the biggest knowledge gap that we face is an almost total lack of multicenter prehabiliation trials that can help us understand how to make prehabilitation work in the real world.

Lastly, and to help address the crucial lack of multicenter prehabiliation trials aligned with real world care, we launched the STRIVE Trial in January 2024. The STRIVE Trial is currently a 5-center trial of virtually supported home-based multimodal prehabilitation that is accessible to any adults preparing for major, elective surgery that aims to initially demonstrate that prehabilitation can be feasibly performed in a pragmatic setting (i.e., without all of the extra support and personnel that come with a tightly controlled trial). If the initial stage of the STRIVE Trial demonstrates feasibility, the trial will convert into a 12-center, pragmatic, registry-linked randomized that will evaluate whether real-world prehabilitation is effective in improving patient-reported recovery after surgery and reducing health system resource use. Findings from the STRIVE trial will be positioned for immediate translation into clinical practice.

Please describe any challenges/barriers that you have encountered thus far and what actions were/will be taken to resolve them?

Our research is informed by an integrated knowledge translation approach, meaning that all stages of our research include perspectives and input from patient partners and knowledge users who will help to implement our findings, like clinicians, health system leaders and other researchers. As such, we’ve found it very helpful to elicit opinions from our diverse partners to overcome barriers that we encounter.

Two examples that come to mind include analysis of our Canadian Prehabiliation Knowledge Network Review and design of the STRIVE Trial.

In preparing to analyze data for our systematic review, we knew that we would need to use complex statistical approaches to account for the many different types of prehabiliation interventions that exist, the different types of surgical patients who receive prehabilitation, and the variety of outcomes that our partners identified as critical to evaluate. A major challenge with using complex statistical analyses can be that their outputs are challenging to interpret. To finalize our approach to data analysis, we held a full team meeting in December 2023 to review the protocol that we’d developed as a team, as well as the initial descriptive data that we had available. Through open review of data, discussion of how statistical methods aligned with clinical interpretation, and small breakout session facilitated by our outstanding research staff, we were able to reach consensus as a group in terms of proceeding with a technique called network meta-analysis because the team felt comfortable with the underlying assumptions required and thought the approach would yield results most directly aligned with patient and clinical information needs.

In designing the STRIVE Trial, we wrestled with important questions about the types of patients that should be included in the trial and the outcomes that we should evaluate. With an executive committee guiding the trial that includes an amazing and engaged patient partner with lived experience having surgery (Ms. Gurlie Kidd: Why more patients are taking a front seat in the medical research | Ottawa Citizen), experts in prehabilitation, surgery, anesthesiology, and biostatistics, we had many perspectives to draw from. Together, reviewing data from our living review that suggested that all types of patients likely benefit from prehabilitation, we decided to be very inclusive in terms of eligibility criteria for the trial. Interestingly, in our experience with the trial to date, this decision has been validated as we’ve had enthusiastic uptake across patient risk groups. In terms of defining primary effectiveness outcomes, our patient-engagement work helped us to select a patient-reported measure of recovery as a primary outcome, but collaboration between our biostatistical leads, Ms. Kidd (our patient partner) and clinical experts helped us to define and prioritize secondary outcomes that would meet the information needs of different future knowledge users.

What are some items/deliverables that you look forward to coming to fruition in the remainder of your KT Fellowship?

Thanks to support from the PSI Mid-Career KT Fellowship, we hope to share a number of deliverables that will help to advance the science and practice of prehabiliation to the benefit of surgical patients in Ontario, Canada and around the world.

In 2024, we look forward to submission and subsequent publication of primary results from the PREPARE Trial, as well as results of our Canadian Prehabilitation Knowledge Network Systematic Review and Network Meta-Analysis. Prior to the completion of the fellowship, I expect that we will publish secondary and long-term outcome data from PREPARE, as well as initial feasibility results from STRIVE.

Having now established our overarching review as a living review, we also have analyses underway that are close to submission addressing questions around the type of patient, program and procedural factors that are associated with greatest benefit from exercise prehabilitation, and an overview of prehabilitation adherence, factors that improve adherence, and how reporting of prehabilitation adherence could be harmonized across the field.

Lastly, another important KT tool is production and dissemination of high-quality clinical practice guidelines, and I’ve been fortunate to be part of teams producing clinical practice guidelines related to prehabilitation. As a member of the American Society of Anesthesiologists’ Taskforce for the Clinical Practice Guideline for Perioperative Care of the Older Surgical Patient, I led the section on prehabilitation (expected publication in early 2025). I will also be contributing to prehabilitation clinical practice guidelines in the UK for cancer patients, due for publication in 2025.

What are some things that surprised you during your fellowship thus far?

Having the opportunity to run a large research program with lots of staff, partners, and interesting studies, I feel like most days bring at least one surprise! But for sure, some surprises over the first year of the Fellowship certainly stand out.

First, even though I’ve been involved in prehabilitation research for almost ten years, I am always surprised at the enthusiasm that patients have toward the opportunity to be involved in prehabilitation. While many trials (including some of our own that aren’t focused on prehab) face challenges recruiting enough participants, our experience with prehabilitation research has been that recruitment sometimes outpaces our expectations. Patients want access to prehabilitation, and in our experience, find that in addition to the exercise and nutritional support, being involved helps them to feel more empowered and meaningfully supported by the healthcare system.

Additionally, the speed with which some of our participants recover from having big, big surgeries is very inspiring. We’ve had people out golfing a couple of weeks after lung resections (How ‘prehab’ exercise could make surgery recovery easier | CTV News) and cross-country skiing five weeks after major bowel cancer surgery (Exercise before surgery? This cancer survivor is a believer | The Ottawa Hospital Foundation (ohfoundation.ca)). We’ve also learned some surprisingly practical lessons about helping patients to get the most out of prehab. While looking back it seems so obvious, by working with patients to get their structured feedback on their experience, we’ve developed better strategies to help people exercise even when it is too hot outside in summer and too cold outside in winter! I think that sometimes as clinicians, we give patients advice that seems so simple (“you should eat better and exercise more before surgery”). But the reality is that changing health behaviors is complex and influenced by so many factors, so unless we talk to the patients who are doing the hard work, we can’t really expect to develop programs that will be effective in real world care.

2023 PSI Graham Farquharson KT Fellow Update: Dr. Krishan Yadav Keeps the Race Going

Once our PSI Knowledge Translation (KT) Fellows take off from the starting line, they make strides as they move their knowledge translation activities and research program forward. As the finish line becomes clearer in their sight, we asked our fellows some questions to share their progress thus far, and what they look forward to in the remainder of their KT Fellowship.

What are some of your accomplishments from the KT Fellowship thus far?

My overall goal for the PSI Graham Farquharson KT Fellowship is to develop and implement better guidance for emergency clinicians when they treat adult patients with bacterial skin and soft tissue infections (SSTIs), which are one of the top 10 reasons to visit a Canadian emergency department. I assembled a multidisciplinary Steering Committee involving key stakeholders: emergency physicians, infectious disease physicians, patient partners with lived experience, pharmacy, nursing, and implementation scientists.

We created a list of key health questions that are important in the diagnosis and management of three types of SSTIs: bacterial cellulitis, skin abscess and life-threatening necrotizing fasciitis. Following this, I identified existing guidelines in the literature for SSTIs. The highest quality guidelines were selected for adaptation using the CAN-IMPLEMENT process, which is a systematic approach to adapting existing guidelines to formulate recommendations for a specific setting and knowledge user.

Our group has now developed the Canadian Emergency Department Best Practices Checklist for Skin and Soft Tissue Infections (SSTI Checklist). This is the first Canadian guidance on diagnosis and management of SSTIs and has been fully endorsed by the Canadian Association of Emergency Physicians. The SSTI Checklist was just accepted for publication with the Canadian Journal of Emergency Medicine. This work has the potential to improve patient outcomes at a national level by improving diagnostic accuracy and treatment strategies, while decreasing intravenous antibiotic overuse, unnecessary hospitalization, and treatment failure.

Please describe any challenges/barriers that you have encountered thus far and what actions were/will be taken to resolve them?

The main barrier to successfully completing a large program of research is the time required given my clinical responsibilities. Fortunately, with the support of this PSI Graham Farquharson KT Fellowship, I have ample protected time to focus on these projects.

What are some items/deliverables that you look forward to coming to fruition in the remainder of your KT Fellowship?

As mentioned, the SSTI Checklist will be published in the next 1-2 months. This summer I will be interviewing emergency physicians to understand barriers and drivers to using the SSTI Checklist. This information will then be used to develop KT tools to better help emergency physicians to use the SSTI Checklist during their clinical practice. Following this, I will conduct a pilot cluster randomized trial using the KT tools we have developed for SSTI Checklist implementation in Canadian emergency departments.

 

2022 PSI Graham Farquharson KT Fellow Update: Dr. Brodie Nolan Keeps the Race Going

Once our PSI Knowledge Translation (KT) Fellows take off from the starting line, they make strides as they move their knowledge translation activities and research program forward. As the finish line becomes clearer in their sight, we asked our fellows some questions to share their progress thus far, and what they look forward to in the remainder of their KT Fellowship.

What are some of your accomplishments from the KT Fellowship thus far?

FIRST60: Prehospital, Trauma, and Resuscitation Sciences

My biggest accomplishment of my KT Fellowship thus far was co-founding the FIRST60: Prehospital, Trauma, and Resuscitation Sciences research group (www.first60.ca). In May 2023, we held a strategic retreat at the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, bringing together investigators and clinicians passionate about advancing prehospital care, trauma, and resuscitation science. This event united experts from various disciplines, including emergency medicine, surgery, transfusion, paramedicine, and nursing, alongside specialists in knowledge translation, quality improvement, education, and clinical epidemiology. Our mission focused on translating scientific research into practical bedside care, aiming to improve patient outcomes from the time of injury or illness through the acute resuscitation. Emphasizing the critical “golden hour” after injury, we named the group FIRST60 as a nod to the crucial first 60 minutes following injury or illness.  As a group, since coming together in May 2023, we have had over 60 peer-reviewed publications and secured over $3.6 million dollars in research funding.

 

SWiFT Canada: Pioneering Prehospital Transfusion Trials in Canada

I am the Principal Investigator for Study of Whole blood in Frontline Trauma (SWiFT) Canada. Over the next year, this pilot study will assess prehospital whole blood versus component therapy (red blood cells + plasma) in traumatic hemorrhage for patients transported by air ambulance. Through this trial we have established a collaborative prehospital trauma network with the involvement of Ornge Air Ambulance, Canadian Blood Services and 6 lead trauma hospitals in Southern Ontario, marking a historic milestone as Canada’s inaugural prehospital transfusion clinical trial.

 

Driving Change in Prehospital Trauma Triage

Timely access to trauma centers is paramount in saving lives. However, for patients in Ontario, geographical constraints often impede prompt trauma care. I am actively investigating the effectiveness and efficiency of the Ontario Field Trauma Triage Standard, which guides paramedics in determining which patients should be directly transported to a trauma centre. Moreover, I am part of a working group that is advocating for revisions to the provincial Field Trauma Triage Standard to ensure alignment with the latest evidence-based practices.  Additionally, I am spearheading the development of a prehospital transfusion prediction score, overseen by one of my PhD students Melissa O’Neill. This innovative score aims to identify patients experiencing massive bleeding in the prehospital setting, enabling paramedics to promptly alert the receiving trauma team for enhanced preparedness and improved patient outcomes.

Please describe any challenges/barriers that you have encountered thus far and what actions were/will be taken to resolve them?

Research funding for trauma and prehospital care is critically low, and this lack of financial support poses significant challenges to advancing the field. The absence of dedicated large funding bodies that specifically highlight injury or prehospital systems of care further exacerbates this problem.  Unlike fields such as cancer or cardiovascular research, which benefit from substantial funding from large organizations, trauma and injury research does not have equivalent support. This is despite trauma and injury being a leading cause of death for young Canadians.  This disparity in funding sources makes it difficult for researchers to secure the necessary financial resources to conduct comprehensive studies. The scarcity of large funding bodies focusing specifically on injury or prehospital care results in limited grant opportunities, hindering the development of innovative treatments and care systems.

Despite the lack of large funding bodies, smaller funding sources, such as Physician Services Incorporated, play a crucial role in supporting early career researchers. Funding through the PSI KT Fellowship has been instrumental in my early research career success. Such funding provides critical financial support that enables researchers to initiate projects, gather preliminary data, and build a foundation for larger studies. This initial support is a key stepping stone to securing more substantial grants in the future.

What are some items/deliverables that you look forward to coming to fruition in the remainder of your KT Fellowship?

Looking ahead to the remainder of my KT Fellowship a few of my deliverables are:

  • Launching the SWiFT Canada Study
  • Piloting a provincial prehospital transfusion registry, to evaluate and inform best practices in prehospital transfusion in Ontario
  • Continuing to grow the footprint of the FIRST60 research group

What are some things that surprised you during your fellowship thus far?

During KT Fellowship, I encountered several unexpected insights and experiences that significantly shaped my perspective on trauma and injury research.

 

The Complexity of Interdisciplinary Trauma Collaboration

One of the most surprising aspects was the complexity and necessity of interdisciplinary collaboration. Trauma and injury research require the integration of various fields, including emergency medicine, surgery, paramedicine, nursing, hematology, epidemiology, public health, and even engineering. Coordinating efforts across these disciplines was challenging but crucial for developing comprehensive solutions to complex problems.  Additionally, the data sources between prehospital and in-hospital are not well linked necessitating multiple data sharing agreements and substantial chart reviews to abstract essential data.

 

The Extent of Funding Challenges

I was aware of the funding challenges in trauma and injury research, but the extent of these challenges was more significant than I anticipated. Securing consistent funding was a continuous struggle, with many projects relying heavily on small, short-term grants. This reality underscored the importance of advocating for more substantial and stable funding sources.

 

The Impact of Technology and Data Analytics

The rapid advancement of technology and data analytics in trauma research was another unexpected discovery.  Machine learning and big data analytics are becoming indispensable in analyzing large datasets and identifying patterns that can inform better clinical practices and policies. These technologies opened new avenues for research that I had not initially considered, with many interesting machine learning projects on the horizon.

 

The Importance of Mentorship and Networking

Lastly, the importance of mentorship and networking in advancing my research career was a pleasant surprise. Having access to experienced mentors provided invaluable guidance, support, and opportunities for collaboration.  It also made the creation of the FIRST60 research group one of the most enjoyable aspects of my research career. Networking with peers and professionals in the field opened doors to new research possibilities and professional growth.

 

Stay Informed

Grant and foundation updates straight to your inbox.